BRIX3000

Product Description

This gel is a product indicated for atraumatic treatment of caries through enzymatic activity (3,000 U/mg *) in which papain is bioencapsulated using E.B.E. technology (Encapsulating Buffer Emulsion)

This is an exclusive technology that immobilizes, confers stability by exponentially increasing the enzymatic activity of the final product compared to current bioencapsulation techniques. Thus, it achieves:

• Higher proteolytic efficacy in the removal of carious tissue
• Less dissolution of the active ingredient through oral liquids
• Greater resistance to unfavorable conditions during storage, without need for refrigeration (the product is stable in a range between 4° and 36° C)
• Greater antibacterial, antifungal force, with an increase in the antiseptic effect on tissue
• pH optimization to immobilize the enzyme until contact with necrotic tissue
• Increase of enzymatic activity of over 50-60%

ADVANTAGES of BRIX3000

• Applicable to patients of all ages, reduces the application of local anesthetics and rotating instruments
• Does not sacrifice healthy tissues and the selective action exerted on necrotic tissue is inactivated by α1-anti-trypsin present in dentin with possibility of remineralization
• No refrigeration is necessary
• Reduces the risk of pulpal exposures
• Patient and dentist peace of mind and absence of stress
• After removal of carious tissue, the cavity presents a surface that facilitates the adhesion of materials to be used for restoration

E.B.E. Technology - Characteristics

This new technology has changed the concept of enzyme encapsulation and releases highly concentrated products:

• Allows high concentrations of enzymes. E.B.E. technology allows concentrations of 3000 U/mg of enzymes, far exceeding the current bioencapsulation technique
• Allows an increase in enzymatic proteolysis
• Requires no refrigeration
• Reduces the time of removal of necrotic tissue
• Causes no trauma
• The enzyme has excellent selectivity
• E.B.E. technology is an exclusive patent of Brix USA LLC

PAPAIN (Enzyme)

Papain is an endoprotein similar to human pepsin, with bactericidal, bacteriostatic and anti-inflammatory properties; it is extracted from the latex of the leaves and fruits of mature green Papaya, Carica papaya, mainly cultivated in tropical countries such as Brazil, India, Ceylon, South Africa and Hawaii.

In relation to other natural enzymes, papain has some advantages such as:

• Quality and enzymatic activity
• Stability even with adverse temperature, humidity and atmospheric pressure conditions
• High commercial value due to the diversity of its uses

Selectivity

Papain acts only on damaged tissue due to the absence of a plasma antiprotease, α1-anti-trypsin, which prevents proteolytic action in normal tissues.

α1-anti-trypsin inhibits protein digestion.

To date, papain contributes to the degradation and elimination of the fibrin "layer" formed by the caries process.