OXIDIZED REGENERATED CELLULOSE HEMOSTATIC AGENT

Oxidized regenerated cellulose is one of the absorbable hemostatic agents used during surgical operations to allow the surgeon to control hemostasis in a balanced manner and to stop bleeding. When a hemostatic agent is used, the risk of surgical intervention resulting from hemostasis is reduced. However, the use of absorbable hemostatic agents based on oxidized regenerated cellulose has become widespread.

Cellulose as a raw material for oxidized regenerated cellulose hemostatic agent is a carbohydrate obtained by the continuous repetition of anhydro-glucose units having a hydroxyl group forming a chain molecule. Furthermore, it is insoluble in water and organic solvents such as benzene, alcohol, acetone, and chloroform. Cellulose of plant origin is abundantly present in nature as biomass. In order to add functionality to cellulose, scientists have conducted various studies over many years. However, cellulose has become usable for various bioapplications over the years.

Oxidized regenerated cellulose, produced in the late 1930s by partial oxidation of the primary hydroxyl groups in the anhydroglucose rings of monocarboxyl cellulose, provides biocompatibility, biosafety, and bioresorption through the presence of carboxylic acid in a ratio of 16-24 % and at the same time plays a major role in hemostasis.

If we look at the use of absorbable hemostatic agents made of oxidized regenerated cellulose, it does not induce an immune response during surgical operations and forms a black gelatinous mass when it comes into contact with blood. This mass promotes clot formation and acts as a physical structure to which blood platelets can adhere. Thereby, through the formation of a platelet-fibrin clot, an accumulation of blood platelets is achieved and bleeding is stopped.

Absorbable hemostatic agents made of oxidized regenerated cellulose are absorbable medical devices that are used in related operations such as gastrointestinal surgery, orthopedics, aesthetic surgery, traumatology, gynecology, dental applications, general surgery, and endoscopic operations.